Open AccessNitration Modifying Function of Proteins, Hormones and Neurotransmitters
Author(s) -
Toshio Nakaki,
Taichi Fujii
Publication year - 1999
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.79.125
Subject(s) - nitration , peroxynitrite , nitric oxide , hormone , chemistry , oxidative stress , function (biology) , biochemistry , oxidative phosphorylation , homeostasis , in vivo , microbiology and biotechnology , biology , enzyme , organic chemistry , superoxide
Several lines of evidence have been accumulated for occurrence of nitration in vivo. In this brief review, we summarized nitration studies on functional changes of proteins, hormones and neurotransmitters, before as well as after the discovery of peroxynitrite. Most of nitrated molecules exhibit less active properties than the parental compounds. It is still unknown whether nitration is merely a footprint of oxidative stress, an important pathway of nitric oxide metabolisms or a part of integral processes for maintaining cellular homeostasis.