Open AccessTeprenone, an Anti-ulcer Agent, Increases Gastric Mucosal Mucus Level via Nitric Oxide in Rats
Author(s) -
Kenji Nishida,
Yoshiji Ohta,
Isao Ishiguro
Publication year - 1998
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - Uncategorized
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.78.519
Subject(s) - nitric oxide , mucus , nitrite , chemistry , nitric oxide synthase , gastric mucosa , medicine , stomach , pharmacology , endocrinology , nitrate , biochemistry , biology , ecology , organic chemistry
We examined whether the increasing action of teprenone (TP) on mucus synthesis and content in rat gastric mucosa is related to nitric oxide (NO) formation via NO synthase (NOS) in the tissue. TP (200 mg/kg)-induced increases in levels of gastric mucosal hexosamine and adherent mucus were inhibited with decreased gastric mucosal NOS activity and nitrite/nitrate concentration by co-administration of NG-monomethyl L-arginine (100 mg/kg), a NOS inhibitor, but not its D-isomer. These results suggest that TP exerts an increasing action on gastric mucus synthesis and content possibly under the condition of maintained NO production via NOS in gastric mucosal tissues, although the precise mechanisms for the action of TP is still unclear.