Effect of KW-8232, a Novel Anti-osteoporotic Agent, on Bone Loss in Sciatic Neurectomized Rats | Zendy

Masako Uchii | Zendy; Takashima Miyuki | Zendy; Sugiyama Tomomi | Zendy; Kosaka Nobuo | Zendy

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Effect of KW-8232, a Novel Anti-osteoporotic Agent, on Bone Loss in Sciatic Neurectomized Rats

Author(s) -

Masako Uchii,

Takashima Miyuki,

Sugiyama Tomomi,

Kosaka Nobuo

Publication year - 1998

Publication title -

the japanese journal of pharmacology

Language(s) - English

Resource type - Journals

eISSN - 1347-3506

pISSN - 0021-5198

DOI - 10.1254/jjp.78.241

Subject(s) - deoxypyridinoline , pyridinoline , bone resorption , resorption , chemistry , osteoporosis , medicine , endocrinology , biochemistry , alkaline phosphatase , osteocalcin , enzyme

The purpose of this study was to evaluate the effects of 3-[bis(4-hydroxyphenyl)methyl]-2-[4-(2-chlorophenyl)-piperazin-1- ylcarbonyl]-1-(2-dimethylaminoethyl) indole methanesulfonate (KW-8232), a novel anti-osteoporotic agent, on bone loss in neurectomized rats. We also investigated the effect of KW-8232 on bone resorption in this animal model. Male Sprague-Dawley rats underwent unilateral hind-limb immobilization by sciatic neurectomy. KW-8232 (3, 10 and 30 mg/kg, p.o.) was effective in inhibiting femoral bone loss. KW-8232 decreased urinary pyridinoline and deoxypyridinoline excretion. These results indicate that KW-8232 effectively prevents the bone loss due to immobilization.

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