Open AccessThe Effect of Vasopressin V1- and V2-Receptor Antagonists on Hemodynamics in Early and Late Phase After Myocardial Infarction in Rats
Author(s) -
Hisayoshi Fujita,
Minoru Yoshiyama,
Kazuhide Takeuchi,
Takashi Omura,
Hiroyuki Yamagishi,
Hiroshi Itoh,
Katuyuki Miura,
Junichi Yoshikawa
Publication year - 1998
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.78.229
Subject(s) - preload , vasopressin receptor , vasopressin , hemodynamics , medicine , antagonist , endocrinology , vasopressin antagonists , receptor
This study was designed to assess the effect of a nonpeptide vasopressin V1-receptor antagonist, OPC-21268, and a vasopressin V2-receptor antagonist, OPC-31260, on hemodynamics in the early phase and the late phase after myocardial infarction in rats. In the early phase, OPC-21268 (30 mg/kg/day) or OPC-31260 (30 mg/kg/day) was orally administered from day 1 to day 5 after the operation; and hemodynamics were measured at day 5, in the late phase from 10 weeks to 11 weeks and measured at the end of 11 weeks. In the early phase, OPC-21268 reduced the left ventricular end-diastolic pressure (LVEDP) concomitantly with the reduction in systemic blood pressure, but did not change LVEDP in the late phase. OPC-31260 reduced LVEDP and central venous pressure in both phases. OPC-21268 improved hemodynamics only in the early phase and OPC-31260 improved it in both phases.