Open AccessInhibition by [Arg8]-Vasopressin of Long Term Potentiation in Guinea Pig Hippocampal Slice
Author(s) -
Einosuke Sakurai,
Takehiko Maeda,
Shuji Kaneko,
Akinori Akaike,
Masamichi Satoh
Publication year - 1998
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.77.103
Subject(s) - long term potentiation , excitatory postsynaptic potential , vasopressin , postsynaptic potential , hippocampal formation , hippocampus , inhibitory postsynaptic potential , guinea pig , biology , antagonist , slice preparation , neuroscience , medicine , chemistry , endocrinology , receptor , electrophysiology , biochemistry
We examined the effects of [Arg8]-vasopressin (AVP) on long term potentiation (LTP) of the field excitatory postsynaptic potentials at CA1 and CA3 synapses in adult guinea pig hippocampal slices. AVP (10 nM) depressed the magnitude of LTP without any effects on basal responses at both synaptic pathways. The depressive effect by AVP at CA1 synapses appears to be receptor-mediated since it was inhibited by an AVP V1-receptor antagonist, [Pmp1,Tyr(Me)2]-AVP. From these results, AVP may play an inhibitory role on the induction of LTP via V1 receptors in the guinea pig hippocampus.