Open AccessInduction of Tumor Necrosis Factor-α mRNA in the Kidney of the Mouse Chronic Hepatitis Model
Author(s) -
Toshihiro Okamoto,
Masami Furuya,
Tomio Yamakawa,
Ken Ichi Yamamura,
Okio Hino
Publication year - 1998
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.76.97
Subject(s) - messenger rna , tumor necrosis factor alpha , kidney , necrosis , tumor necrosis factor α , hepatitis , medicine , chronic hepatitis , biology , immunology , pathology , virus , gene , genetics
Previously we reported the induction of tumor necrosis factor (TNF)-alpha mRNA in the liver of interferon (IFN)-gamma transgenic mouse, which might be the result of IFN-gamma gene expression. In the present study, IFN-gamma mRNA was induced in the liver, kidney and lung. TNF-alpha mRNA was, however, induced in the liver and kidney, but not in the lung. Induction of interleukin (IL)-2 and IL-1beta mRNA was lacking in any of these organs. The present result showed the induction of TNF-alpha mRNA expression in the kidney of transgenic mouse.