Induction of Tumor Necrosis Factor-α mRNA in the Kidney of the Mouse Chronic Hepatitis Model | Zendy

Toshihiro Okamoto | Zendy; Masami Furuya | Zendy; Tomio Yamakawa | Zendy; Ken–ichi Yamamura | Zendy; Okio Hino | Zendy

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Induction of Tumor Necrosis Factor-α mRNA in the Kidney of the Mouse Chronic Hepatitis Model

Author(s) -

Toshihiro Okamoto,

Masami Furuya,

Tomio Yamakawa,

Ken–ichi Yamamura,

Okio Hino

Publication year - 1998

Publication title -

the japanese journal of pharmacology

Language(s) - English

Resource type - Journals

eISSN - 1347-3506

pISSN - 0021-5198

DOI - 10.1254/jjp.76.97

Subject(s) - messenger rna , tumor necrosis factor alpha , kidney , necrosis , tumor necrosis factor α , hepatitis , medicine , chronic hepatitis , biology , immunology , pathology , virus , gene , genetics

Previously we reported the induction of tumor necrosis factor (TNF)-alpha mRNA in the liver of interferon (IFN)-gamma transgenic mouse, which might be the result of IFN-gamma gene expression. In the present study, IFN-gamma mRNA was induced in the liver, kidney and lung. TNF-alpha mRNA was, however, induced in the liver and kidney, but not in the lung. Induction of interleukin (IL)-2 and IL-1beta mRNA was lacking in any of these organs. The present result showed the induction of TNF-alpha mRNA expression in the kidney of transgenic mouse.

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