Open AccessRole of Nitric Oxide in the Convulsions Following the Coadministration of Enoxacin With Fenbufen in Mice
Author(s) -
Tohru Masukawa,
Kunio Nakanishi,
Reiko Natsuki
Publication year - 1998
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.76.425
Subject(s) - enoxacin , chemistry , nitric oxide synthase , pharmacology , anticonvulsant , nitric oxide , enzyme inhibitor , convulsion , enzyme , epilepsy , biochemistry , medicine , antibiotics , organic chemistry , ofloxacin , psychiatry , ciprofloxacin
Effects of nitric oxide (NO) synthase inhibitors on the enoxacin-induced convulsions were examined in mice pretreated with fenbufen. 7-nitroindazole markedly suppressed the incidence of convulsions, whereas L-arginine did not modify the convulsions at all. The suppression of the convulsions by 7-nitroindazole was not reversed by the pretreatment of L-arginine. Brain NO synthase activity was significantly raised at 30 min after enoxacin when combined with fenbufen. The increased NO synthase activity was found to be suppressed by the pretreatment of 7-nitroindazole. These findings suggest that endogenous NO may be involved as a proconvulsant substance in the development of enoxacin-induced convulsions in mice pretreated with fenbufen.