Repeated Injections of Nicergoline Increase the Nerve Growth Factor Level in the Aged Rat Brain | Zendy

Takeshi Nishio | Zendy; N Sunohara | Zendy; Shoei Furukawa | Zendy; Ichiro Akiguchi | Zendy; Yukitsuka Kudo | Zendy

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Repeated Injections of Nicergoline Increase the Nerve Growth Factor Level in the Aged Rat Brain

Author(s) -

Takeshi Nishio,

N Sunohara,

Shoei Furukawa,

Ichiro Akiguchi,

Yukitsuka Kudo

Publication year - 1998

Publication title -

the japanese journal of pharmacology

Language(s) - English

Resource type - Journals

eISSN - 1347-3506

pISSN - 0021-5198

DOI - 10.1254/jjp.76.321

Subject(s) - nerve growth factor , medicine , endocrinology , body weight , anesthesia , receptor

We studied whether nicergoline, clinically active in chronic cerebrovascular insufficiency, influences nerve growth factor (NGF) levels in the rat brain. In young Fischer rats, repeated intraperitoneal injections of nicergoline (0.3 and 1.0 mg/kg body weight) did not show any effects on frontal NGF contents determined by a highly sensitive enzyme immunoassay. In aged rats, 22-month-old, however, repeated injections of nicergoline (1.0 mg/kg body weight) induced a significant increase in the NGF level in the frontal region.

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