Open AccessRepeated Injections of Nicergoline Increase the Nerve Growth Factor Level in the Aged Rat Brain
Author(s) -
Takeshi Nishio,
Nobuhiko Sunohara,
Shoei Furukawa,
Ichiro Akiguchi,
Yoshihisa Kudo
Publication year - 1998
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.76.321
Subject(s) - nerve growth factor , medicine , endocrinology , body weight , anesthesia , receptor
We studied whether nicergoline, clinically active in chronic cerebrovascular insufficiency, influences nerve growth factor (NGF) levels in the rat brain. In young Fischer rats, repeated intraperitoneal injections of nicergoline (0.3 and 1.0 mg/kg body weight) did not show any effects on frontal NGF contents determined by a highly sensitive enzyme immunoassay. In aged rats, 22-month-old, however, repeated injections of nicergoline (1.0 mg/kg body weight) induced a significant increase in the NGF level in the frontal region.