Open AccessPsychological Stress Induces Heat Shock Protein 70 Expression in Rat Aorta
Author(s) -
Minoru Isosaki,
Taku Nakashima
Publication year - 1998
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.76.305
Subject(s) - hsp70 , aorta , heat shock protein , shock (circulatory) , messenger rna , psychological stress , heat stress , medicine , endocrinology , biology , chemistry , biochemistry , zoology , gene , clinical psychology
Psychological stress without any physical stimuli caused a rapid and marked increase in the level of heat shock protein (HSP) 70 mRNA in rat aorta, but had little effect on the other tested tissues. The maximum increase in HSP70 mRNA level in the aorta was observed at 0.5-1 hr after the stress, and then it declined. Moreover, this stress also increased the level of HSP70 protein in the aorta, but had little effect on the other tested tissues. These results indicate that exposure of rats to mild psychological stress results in the induction of HSP70, especially in the blood vessels.