Effects of Concanavalin A on Cytokine mRNA Expression in Mouse Liver. | Zendy

Toshihiro Okamoto | Zendy; Tadashi Kobayashi | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Effects of Concanavalin A on Cytokine mRNA Expression in Mouse Liver.

Author(s) -

Toshihiro Okamoto,

Tadashi Kobayashi

Publication year - 1997

Publication title -

the japanese journal of pharmacology

Language(s) - English

Resource type - Journals

eISSN - 1347-3506

pISSN - 0021-5198

DOI - 10.1254/jjp.75.199

Subject(s) - concanavalin a , cytokine , messenger rna , gene expression , interleukin 2 , biology , tumor necrosis factor alpha , cytokine receptor , lymphocyte , microbiology and biotechnology , endocrinology , medicine , gene , immunology , biochemistry , in vitro

The effects of concanavalin A (Con A) on liver cytokine gene expression was studied in mice. The CD4 mRNA expression in normal liver suggests the presence of CD4+ T cells. The administration of Con A induced interleukin (IL)-1beta, IL-2 and IL-2 receptor mRNAs, which implies lymphocyte activation in the liver. Interferon-gamma and tumor necrosis factor-alpha mRNA expressions were increased gradually. The present results showed that Con A induced liver cytokine genes. This cytokine gene induction might have been the result of lymphocyte activation in the liver.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research