Open AccessEffects of Concanavalin A on Cytokine mRNA Expression in Mouse Liver.
Author(s) -
Toshihiro Okamoto,
Tadashi Kobayashi
Publication year - 1997
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.75.199
Subject(s) - concanavalin a , cytokine , messenger rna , gene expression , interleukin 2 , biology , tumor necrosis factor alpha , cytokine receptor , lymphocyte , microbiology and biotechnology , endocrinology , medicine , gene , immunology , biochemistry , in vitro
The effects of concanavalin A (Con A) on liver cytokine gene expression was studied in mice. The CD4 mRNA expression in normal liver suggests the presence of CD4+ T cells. The administration of Con A induced interleukin (IL)-1beta, IL-2 and IL-2 receptor mRNAs, which implies lymphocyte activation in the liver. Interferon-gamma and tumor necrosis factor-alpha mRNA expressions were increased gradually. The present results showed that Con A induced liver cytokine genes. This cytokine gene induction might have been the result of lymphocyte activation in the liver.