Open AccessComparative Study of the Effects of Indomethacin and NS-398, a Selective Cyclooxygenase 2 Inhibitor, on Duodenal Bicarbonate Secretion Induced by Luminal Acidification in Rats.
Author(s) -
Kazumi Iwata,
Naofumi Murakami,
Hiroshi Takase,
Takako Saitô,
Tomofumi Naruse
Publication year - 1997
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.75.191
Subject(s) - bicarbonate , histamine , secretion , cyclooxygenase , medicine , chemistry , duodenum , endocrinology , enzyme , biochemistry
To clarify the mechanisms of duodenal ulcerogenic activity of non-steroidal anti-inflammatory drugs (NSAIDs), the effects of indomethacin (IND) on acid-stimulated duodenal bicarbonate secretion and histamine-induced duodenal ulcerogenic responses were studied in comparison with NS-398, a selective cyclooxygenase (COX)-2 inhibitor, in rats. IND (1 and 5 mg/kg, s.c.) significantly decreased duodenal bicarbonate secretion and potentiated duodenal lesion in a dose-dependent manner. On the other hand, NS-398 had no effect on these parameters. These findings suggest that duodenal ulcerogenicity of IND in the presence of histamine is mainly due to the inhibitory action on acid-stimulated bicarbonate secretion mediated by COX-1, but not by COX-2.