Effect of Salmon-Calcitonin on In Vitro Opioid Withdrawal. | Zendy

M.J. Alfaro | Zendy; Beatriz MartínFernández | Zendy; Carlos Goicoechea | Zendy; M. Isabel Martin | Zendy

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Effect of Salmon-Calcitonin on In Vitro Opioid Withdrawal.

Author(s) -

M.J. Alfaro,

Beatriz MartínFernández,

Carlos Goicoechea,

M. Isabel Martin

Publication year - 1997

Publication title -

the japanese journal of pharmacology

Language(s) - English

Resource type - Journals

eISSN - 1347-3506

pISSN - 0021-5198

DOI - 10.1254/jjp.75.101

Subject(s) - excitatory postsynaptic potential , morphine , (+) naloxone , contraction (grammar) , inhibitory postsynaptic potential , in vitro , postsynaptic potential , chemistry , acetylcholine , endocrinology , calcitonin , pharmacology , medicine , opioid , receptor , biochemistry

The effect on the in vitro withdrawal sign induced by naloxone in morphine-dependent guinea pig ileum has been analyzed. Salmon calcitonin (s-CT) dose-dependently reduced the force of the contraction induced by naloxone in morphine incubated tissues, but did not modify the contraction induced by administration of acetylcholine or substance P in non-treated tissues. Therefore, the effect of s-CT in morphine incubated tissues may not be attributable to postsynaptic mechanisms, and an inhibitory modulation of the excitatory pathways triggered by naloxone would be suggested. In conclusion, s-CT is able to prevent the withdrawal sign in vitro.

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