Open AccessEffect of Salmon-Calcitonin on In Vitro Opioid Withdrawal.
Author(s) -
Alfaro Mj,
Beatriz Martín-Fernández,
Carlos Goicoechea,
Martín Mi
Publication year - 1997
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.75.101
Subject(s) - excitatory postsynaptic potential , morphine , (+) naloxone , contraction (grammar) , inhibitory postsynaptic potential , in vitro , postsynaptic potential , chemistry , acetylcholine , endocrinology , calcitonin , pharmacology , medicine , opioid , receptor , biochemistry
The effect on the in vitro withdrawal sign induced by naloxone in morphine-dependent guinea pig ileum has been analyzed. Salmon calcitonin (s-CT) dose-dependently reduced the force of the contraction induced by naloxone in morphine incubated tissues, but did not modify the contraction induced by administration of acetylcholine or substance P in non-treated tissues. Therefore, the effect of s-CT in morphine incubated tissues may not be attributable to postsynaptic mechanisms, and an inhibitory modulation of the excitatory pathways triggered by naloxone would be suggested. In conclusion, s-CT is able to prevent the withdrawal sign in vitro.