Effect of Japanese Angelica Root Extract on Pentobarbital-Induced Sleep in Group-Housed and Socially Isolated Mice: Evidence for the Central Action. | Zendy

Kinzo Matsumoto | Zendy; Shin-ichi Kohno | Zendy; Yasuhiro Tezuka | Zendy; Shigetoshi Kadota | Zendy; Takeshi Nabe | Zendy

Open Access

Effect of Japanese Angelica Root Extract on Pentobarbital-Induced Sleep in Group-Housed and Socially Isolated Mice: Evidence for the Central Action.

Author(s) -

Kinzo Matsumoto,

Shin-ichi Kohno,

Yasuhiro Tezuka,

Shigetoshi Kadota,

Takeshi Nabe

Publication year - 1997

Publication title -

the japanese journal of pharmacology

Language(s) - English

Resource type - Journals

eISSN - 1347-3506

pISSN - 0021-5198

DOI - 10.1254/jjp.73.353

Subject(s) - yohimbine , pentobarbital , endocrinology , agonist , medicine , sleep (system call) , methoxamine , alpha (finance) , chemistry , pharmacology , psychology , antagonist , receptor , developmental psychology , psychometrics , construct validity , computer science , operating system

We investigated the effect of the aqueous extract of Japanese angelica root (JAR) on pentobarbital (PB) sleep in group-housed and socially isolated mice. The JAR extract (1.25-2.5 g/kg, p.o.) dose-dependently reversed the decrease in PB sleep caused by isolation stress without affecting PB sleep in group-housed mice. The JAR extract (2.5 g/kg, p.o.) also antagonized the decrease in PB sleep caused by the alpha 2-adrenoceptor antagonists yohimbine and idazoxan (1 mg/kg, i.p.) and the alpha 1-adrenoceptor agonist methoxamine (200 nmol, i.c.v.) in group-housed mice. These results suggest that the JAR extract reverses changes in the arousal level caused by isolation stress and the activation of central noradrenergic systems.

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