Open AccessInhibition by Adrenomedullin of the Adrenergic Neurogenic Response in Canine Mesenteric Arteries
Author(s) -
Tomio Okamura,
Jianxin Zhang,
Kenji Kangawa,
Noboru Toda
Publication year - 1997
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.73.259
Subject(s) - adrenomedullin , calcitonin gene related peptide , calcitonin , medicine , mesenteric arteries , endocrinology , stimulation , receptor , adrenergic , inhibitory postsynaptic potential , adrenergic receptor , pressor response , chemistry , neuropeptide , blood pressure , artery , heart rate
Adrenomedullin (AM) inhibited the pressor action caused by transmural electrical stimulation in perfused isolated canine mesenteric arteries. The inhibitory potency of AM was greater than that of calcitonin gene-related peptide (CGRP) or proadrenomedullin NH2-terminal 20 peptide (PAMP). [8-37]CGRP did not affect the inhibitory action of AM, but suppressed the CGRP-induced inhibition. It may be concluded that AM has an ability to inhibit adrenergic neuronal transmission without the mediation of CGRP1 receptors in the peripheral vasculature, and this inhibition partly participates in the potent hypotensive action of AM.