Open Access.BETA.1-Adrenoceptor-Mediated Relaxation by Norepinephrine in Dog Hepatic Arteries.
Author(s) -
Susumu Shiraishi,
Tomio Okamura,
Noboru Toda
Publication year - 1997
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.73.101
Subject(s) - norepinephrine , prazosin , medicine , papaverine , endocrinology , coronary arteries , adrenergic receptor , artery , chemistry , receptor , dopamine , antagonist
Dog hepatic arterial strips treated with prazosin responded to norepinephrine with concentration-related, endothelium-independent relaxations, the maximal response being 81.7% of the papaverine-induced maximal relaxation that was markedly greater than that in renal arteries. The norepinephrine-induced relaxation in hepatic arteries was significantly attenuated by metoprolol but not influenced by butoxamine. Relaxant responses to norepinephrine of dog hepatic arteries appear to be mediated by the beta1-adrenoceptor subtype, like those of coronary arteries. Evidence for functioning of the beta1-subtype in hepatic arteries would contribute to the analysis of neural and hormonal regulation of blood flow in the liver.