The Mode of Inhibitory Action of a-Mangostin, a Novel Inhibitor, on the Sarcoplasmic Reticulum Ca2+-Pumping ATPase from Rabbit Skeletal Muscle | Zendy

KenIchi Furukawa | Zendy; Kazuki Shibusawa | Zendy; Nattaya Chairungsrilerd | Zendy; Tomihisa Ohta | Zendy; Shigeo Nozoe | Zendy; Yasushi Ohizumi | Zendy

Open Access

The Mode of Inhibitory Action of a-Mangostin, a Novel Inhibitor, on the Sarcoplasmic Reticulum Ca2+-Pumping ATPase from Rabbit Skeletal Muscle

Author(s) -

KenIchi Furukawa,

Kazuki Shibusawa,

Nattaya Chairungsrilerd,

Tomihisa Ohta,

Shigeo Nozoe,

Yasushi Ohizumi

Publication year - 1996

Publication title -

the japanese journal of pharmacology

Language(s) - English

Resource type - Journals

eISSN - 1347-3506

pISSN - 0021-5198

DOI - 10.1254/jjp.71.337

Subject(s) - endoplasmic reticulum , inhibitory postsynaptic potential , rabbit (cipher) , atpase , skeletal muscle , chemistry , microbiology and biotechnology , pharmacology , endocrinology , biology , biochemistry , enzyme , computer science , computer security

alpha-Mangostin, the principal ingredient of the fruit hull of Garcinia mangostana, caused a concentration-dependent decrease in the activities of both Ca(2+)-ATPase and Ca(2+)-transport of the sarcoplasmic reticulum from rabbit skeletal muscle with an IC50 value of 5 microM. Neither Ca2+ release nor other enzyme activities were affected by alpha-mangostin. Kinetic analysis of the inhibitory effects of alpha-mangostin on Ca(2+)-ATPase suggests that the inhibition of the ATPase is a noncompetitive-type with respect to ATP or Ca2+. alpha-Mangostin may become a useful pharmacological tool for clarifying the physiological functions of Ca(2+)-pumping ATPase and sarcoplasmic reticulum.

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