Open AccessThe Effect of KW-4679, an Antiallergic Drug, on Experimental Allergic Rhinitis in Guinea Pigs: Effects on Nasal Blockage
Author(s) -
Toshihiko Kaise,
Kenji Ohmori,
Yasuo Sakakura,
Kotaro Ukai
Publication year - 1995
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.69.435
Subject(s) - nasal cavity , acoustic rhinometry , antigen , medicine , pharmacology , volume (thermodynamics) , drug , chemistry , anesthesia , immunology , surgery , physics , quantum mechanics
We investigated the effect of KW-4679 (Z-11-(dimethylaminopropyliden)-6,11-dihydrodibenzoxepin-2-a cetic acid hydrochloride), an antiallergic agent, on the nasal blockage induced by antigen challenge into the nostrils of actively sensitized guinea pigs. The change of the nasal cavity volume caused by nasal mucosal swelling after antigen challenge was measured by acoustic rhinometry. Oral administration of KW-4679 (0.01-10 mg/kg) significantly inhibited the decrease in the nasal cavity volume at 10 min, 30 min and 6 hr after antigen challenge. Ketotifen (1-10 mg/kg, p.o.) also inhibited the decrease in the nasal cavity volume after antigen challenge. These results indicate that KW-4679 may be useful for the treatment of allergic rhinitis.