Inhibitory Effect of KBT-3022, a New Anti-platelet Agent, on Infiltration of Polymorphonuclear Leukocytes Induced by Leukotriene B4 or Formyl-Methionyl-Leucyl-Phenylalanine in Mice | Zendy

Koichi Yokota | Zendy; Noriko Yamamoto | Zendy; Yuji Obata | Zendy; Minoru Oda | Zendy

Open Access

Inhibitory Effect of KBT-3022, a New Anti-platelet Agent, on Infiltration of Polymorphonuclear Leukocytes Induced by Leukotriene B4 or Formyl-Methionyl-Leucyl-Phenylalanine in Mice

Author(s) -

Koichi Yokota,

Noriko Yamamoto,

Yuji Obata,

Minoru Oda

Publication year - 1995

Publication title -

the japanese journal of pharmacology

Language(s) - English

Resource type - Journals

eISSN - 1347-3506

pISSN - 0021-5198

DOI - 10.1254/jjp.68.353

Subject(s) - leukotriene b4 , polymorphonuclear leukocyte , infiltration (hvac) , chemistry , inhibitory postsynaptic potential , platelet , granulocyte , phenylalanine , pharmacology , immunology , biochemistry , inflammation , medicine , materials science , in vitro , amino acid , composite material

We devised a method for evaluating polymorphonuclear leukocyte (PMN) infiltration in vivo employing an air bleb technique combined with measurement of myeloperoxidase (MPO) activity, and the effects of some anti-platelet agents were evaluated. KBT-3022 (ethyl 2-[4,5-bis(4-methoxyphenyl)thiazol-2-yl]pyrrol-1-ylacetate) and cilostazol inhibited the increase in MPO activity in the connective tissue around the air bleb induced by leukotriene B4 (LTB4) and formyl-methionyl-leucyl-phenylalanine (fMLP). Indomethacin inhibited only the fMLP-induced increase in MPO activity, but ticlopidine hydrochloride and acetylsalicylic acid had no effect. Histologic observation confirmed the inhibition of PMN infiltration by KBT-3022. These results indicate that KBT-3022 may be a potent inhibitor of both LTB4- and fMLP-induced infiltration of PMNs.

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