Open AccessEffects of KW-3902, an Adenosine A1-Receptor Antagonist, on Ascites Volume in Puromycin Aminonucleoside (PAN)-Induced Nephrotic Rats
Author(s) -
Hideaki Kusaka,
Ken Nagashima,
Akira Karasawa
Publication year - 1995
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.68.213
Subject(s) - diuretic , medicine , endocrinology , antagonist , furosemide , nephrosis , adenosine , nephrotic syndrome , edema , puromycin , ascites , chemistry , receptor , biochemistry , protein biosynthesis
We investigated the effects of KW-3902 (8-(noradamantan-3-yl)-1,3-dipropylxanthine), a potent adenosine A1-receptor antagonist, on the nephrotic edema induced by puromycin aminonucleoside (PAN; 100 mg/kg, i.v.) in rats. The treatment with PAN decreased urine volume and urinary excretions of sodium and potassium, resulting in the ascites formation in 7 days. In rats with the nephrosis, KW-3902 (0.01-1 mg/kg/day for 3 days, p.o.) showed diuretic effects and reduced the volume of ascites, as was the case with furosemide (30 mg/kg/day) and trichlormethiazide (1 mg/kg/day). These results suggest that even in the nephrotic state, the adenosine A1-receptor antagonist can be an effective diuretic to ameliorate edema.