Open AccessVasodilative Effect of Adrenomedullin in Isolated Arteries of the Dog
Author(s) -
Kumi Nakamura,
Hiroshi Toda,
Kiyoshi Terasako,
Masahiro Kakuyama,
Yoshio Hatano,
Kenjiro Mori,
Kenji Kangawa
Publication year - 1995
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.67.259
Subject(s) - adrenomedullin , calcitonin gene related peptide , mesenteric arteries , medicine , calcitonin , coronary arteries , vasodilation , femoral artery , endocrinology , artery , cardiology , neuropeptide , receptor
Adrenomedullin is known to induce profound hypotension in vivo, but the direct effect of this peptide on isolated arteries has not been demonstrated. This study estimated the vasodilative effects of adrenomedullin in comparison with those of calcitonin gene-related peptide (CGRP) in basilar, mesenteric, coronary, renal and femoral arteries isolated from the dog. Adrenomedullin (3 to 100 nM) and CGRP (1 to 30 nM) induced concentration-dependent relaxation of these arteries with and without endothelium, and the relaxing effects were slightly greater in endothelium-intact arteries than in denuded ones. The vasodilative potency of adrenomedullin relative to CGRP was smaller in the femoral artery than in basilar, mesenteric, coronary and renal arteries.