Open AccessEffects of Kamikihito, a Traditional Chinese Medicine, on Neurotransmitter Receptor Binding in the Aged Rat Brain Determined by In Vitro Autoradiography (1): Changes in the [3H]QNB Binding
Author(s) -
Tetsuo Hayashi,
Kiyofumi Yamada,
Takaaki Hasegawa,
Seiichi Ishihara,
Tsutomu Kameyama,
Tadaomi Morimasa,
Takao Kaneyuki,
Toshikiyo Shohmori,
Toshitaka Nabeshima
Publication year - 1994
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.64.303
Subject(s) - quinuclidinyl benzilate , medicine , endocrinology , chemistry , neurotransmitter , in vitro , receptor , pharmacology , muscarinic acetylcholine receptor , biochemistry
Using in vitro autoradiography, we investigated the effects of Kamikihito (KKT), a traditional Chinese medicine, on the specific binding of [3H]quinuclidinyl benzilate (QNB) and [3H]N-(1-[2-thienyl]cyclohexyl)-3,4-piperidine (TCP) in the rat brain. The Bmax but not the Kd values for [3H]QNB binding to the caudate/putamen and accumbens in aged rats were lower than those in young rats. The [3H]TCP binding was also decreased in aged rats compared with that in young rats. Long-term administration of KKT modulated the [3H]QNB binding in young but not aged rats.