Involvement of Carbon Monoxide in Long-Term Potentiation in the Dentate Gyrus of Anesthetized Rats | Zendy

Yuji Ikegaya | Zendy; Hiroshi Saitō | Zendy; Norio Matsuki | Zendy

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Involvement of Carbon Monoxide in Long-Term Potentiation in the Dentate Gyrus of Anesthetized Rats

Author(s) -

Yuji Ikegaya,

Hiroshi Saitō,

Norio Matsuki

Publication year - 1994

Publication title -

the japanese journal of pharmacology

Language(s) - English

Resource type - Journals

eISSN - 1347-3506

pISSN - 0021-5198

DOI - 10.1254/jjp.64.225

Subject(s) - long term potentiation , dentate gyrus , chemistry , hippocampal formation , tetanic stimulation , carbon monoxide , stimulation , hippocampus , pharmacology , neuroscience , biochemistry , medicine , biology , receptor , catalysis

To elucidate the role of carbon monoxide (CO) in hippocampal long-term potentiation (LTP), the effect of an inhibitor of heme oxygenase, which produces carbon monoxide, was investigated in the dentate gyrus of anesthetized rats. Administration of zinc protoporphyrin IX (100 nmol, i.c.v.) 30 min before the tetanic stimulation of 30 pulses at 60 Hz attenuated the intensity of LTP. However, this drug did not affect the established LTP. These results suggest that CO participates in the generation of LTP in vivo.

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