Effect of a New Psychoactive Compound, MCI-225, on Brain Monoamine Metabolism in Rats | Zendy

Ryozo Oishi | Zendy; Yoshinori Itoh | Zendy; Naoto Adachi | Zendy; Kiyomi Saeki | Zendy

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Effect of a New Psychoactive Compound, MCI-225, on Brain Monoamine Metabolism in Rats

Author(s) -

Ryozo Oishi,

Yoshinori Itoh,

Naoto Adachi,

Kiyomi Saeki

Publication year - 1993

Publication title -

the japanese journal of pharmacology

Language(s) - English

Resource type - Journals

eISSN - 1347-3506

pISSN - 0021-5198

DOI - 10.1254/jjp.63.261

Subject(s) - monoamine neurotransmitter , serotonergic , hypothalamus , medicine , endocrinology , chemistry , probenecid , striatum , microdialysis , hippocampus , metabolism , cerebral cortex , serotonin , 5 hydroxyindoleacetic acid , norepinephrine , central nervous system , dopamine , biology , receptor

Effect of MCI-225 on brain monoamine metabolism was examined in rats. MCI-225 (30 mg/kg, p.o.) had no influence on noradrenaline (NA) levels, but significantly inhibited the NA turnover in the hippocampus and hypothalamus. This compound also significantly increased the 5-hydroxyindoleacetic acid (5-HIAA)/5-hydroxytryptamine ratio in the cerebral cortex, hippocampus and striatum; and it enhanced the probenecid-induced 5-HIAA accumulation in the striatum. In the microdialysis study, MCI-225 markedly increased the NA output, but decreased the 3,4-dihydroxyphenylethyleneglycol output from the hypothalamus of urethane-anesthetized rats. These results suggest that MCI-225 enhances both noradrenergic and serotonergic function by inhibiting NA uptake and accelerating 5-HT turnover, respectively.

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