Open AccessModification by Hydroxyl Radicals of Functional Reactivity in Rabbit Lingual Artery
Author(s) -
Hideto Sasaki,
Eiichiro Okabe
Publication year - 1993
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.62.407
Subject(s) - benzphetamine , ovalbumin , chemistry , ethylmorphine , cytochrome b5 , cytochrome , radical , cytochrome p450 , reductase , pharmacology , intraperitoneal injection , demethylase , enzyme , biochemistry , medicine , endocrinology , immunology , biology , immune system , epigenetics , gene
Rats were immunized by intraperitoneal injection of ovalbumin emulsified with Freund incomplete adjuvant, and then the effect of an intravenous challenge with ovalbumin on hepatic drug-metabolizing enzyme activities was examined. The cytochrome P-450 content and ethylmorphine N-demethylase, benzphetamine N-demethylase, arylhydrocarbon hydroxylase and 7-ethoxycoumarin O-deethylase activities significantly decreased in rats treated with ovalbumin compared with control groups treated with saline, whereas there was no significant reduction in cytochrome b5, NADPH-cytochrome c reductase and NADH-cytochrome c reductase.