Modification by Hydroxyl Radicals of Functional Reactivity in Rabbit Lingual Artery | Zendy

Hideto Sasaki | Zendy; Eiichiro Okabe | Zendy

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Modification by Hydroxyl Radicals of Functional Reactivity in Rabbit Lingual Artery

Author(s) -

Hideto Sasaki,

Eiichiro Okabe

Publication year - 1993

Publication title -

the japanese journal of pharmacology

Language(s) - English

Resource type - Journals

eISSN - 1347-3506

pISSN - 0021-5198

DOI - 10.1254/jjp.62.407

Subject(s) - benzphetamine , ovalbumin , chemistry , ethylmorphine , cytochrome b5 , cytochrome , radical , cytochrome p450 , reductase , pharmacology , intraperitoneal injection , demethylase , enzyme , biochemistry , medicine , endocrinology , immunology , biology , immune system , epigenetics , gene

Rats were immunized by intraperitoneal injection of ovalbumin emulsified with Freund incomplete adjuvant, and then the effect of an intravenous challenge with ovalbumin on hepatic drug-metabolizing enzyme activities was examined. The cytochrome P-450 content and ethylmorphine N-demethylase, benzphetamine N-demethylase, arylhydrocarbon hydroxylase and 7-ethoxycoumarin O-deethylase activities significantly decreased in rats treated with ovalbumin compared with control groups treated with saline, whereas there was no significant reduction in cytochrome b5, NADPH-cytochrome c reductase and NADH-cytochrome c reductase.

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