Open Accessα1-Adrenoceptor Subtype in the Rat Prostate Is Preferentially the α Type
Author(s) -
Akio Fujimura,
Tsuyoshi Shiga,
Toshiaki Sudoh,
Kyoichi Ohashi,
Akio Ebihara
Publication year - 1993
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.62.403
Subject(s) - furosemide , doxazosin , diuretic , endocrinology , prostate , adrenergic receptor , blockade , medicine , chemistry , alpha (finance) , receptor , pharmacology , sodium , cancer , surgery , blood pressure , construct validity , organic chemistry , patient satisfaction
Influence of alpha-receptor blockade on the time-dependent change in the effect of furosemide (a loop diuretic agent) was examined. Furosemide (30 mg/kg) was given orally to the doxazosin (an alpha 1-blocker)- or vehicle-treated rats at 12 AM or 12 PM. Urine volume and urinary excretions of of sodium and furosemide for 8 hr were significantly greater at 12 AM than at 12 PM in the vehicle-treated animals. However, such time-dependent changes in these parameters disappeared in the doxazosin-treated rats. These results suggest that the alpha 1-receptor-mediated stimuli are involved in the mechanism of the time-dependent change in the effect of furosemide.