Marked Species-Difference in the Vascular Angiotensin II-Forming Pathways: Humans versus Rodents | Zendy

Hideki Okunishi | Zendy; Yuko Oka | Zendy; Naotaka Shiota | Zendy; Tatsuhiko Kawamoto | Zendy; Keifu Song | Zendy; Mizuo Miyazaki | Zendy

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Marked Species-Difference in the Vascular Angiotensin II-Forming Pathways: Humans versus Rodents

Author(s) -

Hideki Okunishi,

Yuko Oka,

Naotaka Shiota,

Tatsuhiko Kawamoto,

Keifu Song,

Mizuo Miyazaki

Publication year - 1993

Publication title -

the japanese journal of pharmacology

Language(s) - English

Resource type - Journals

eISSN - 1347-3506

pISSN - 0021-5198

DOI - 10.1254/jjp.61.371

Subject(s) - angiotensin ii , renin–angiotensin system , angiotensin converting enzyme , medicine , significant difference , endocrinology , rodent , enzyme , angiotensin iii , chemistry , angiotensin ii receptor type 1 , biology , biochemistry , blood pressure , ecology

We investigated the effects of class III antiarrhythmic agents, d-sotalol, E-4031 and MS-551, on the currents of two cloned K channels, Kv1.2 (IKv1.2) and Kv1.4(IKv1.4), by using the Xenopus oocyte expression system. Both IKv1.2 and IKv1.4 were sensitive to 4-aminopyridine and quinidine, but insensitive to tetraethylammonium, d-sotalol, E-4031 and MS-551. The results suggest that some types of structural proteins may be necessary for class III agents to inhibit the cardiac cloned K channels.

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