Open AccessMarked Species-Difference in the Vascular Angiotensin II-Forming Pathways: Humans versus Rodents
Author(s) -
Toshio Yamagishi,
Kuniaki Ishii,
Norio Taira
Publication year - 1993
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.61.371
Subject(s) - angiotensin ii , renin–angiotensin system , angiotensin converting enzyme , medicine , significant difference , endocrinology , rodent , enzyme , angiotensin iii , chemistry , angiotensin ii receptor type 1 , biology , biochemistry , blood pressure , ecology
We investigated the effects of class III antiarrhythmic agents, d-sotalol, E-4031 and MS-551, on the currents of two cloned K channels, Kv1.2 (IKv1.2) and Kv1.4(IKv1.4), by using the Xenopus oocyte expression system. Both IKv1.2 and IKv1.4 were sensitive to 4-aminopyridine and quinidine, but insensitive to tetraethylammonium, d-sotalol, E-4031 and MS-551. The results suggest that some types of structural proteins may be necessary for class III agents to inhibit the cardiac cloned K channels.