Open AccessThe Repeated Administration of Ketamine Induces an Enhancement of Its Stimulant Action in Mice
Author(s) -
Yoshitaka Uchihashi,
Hisashi Kuribara,
Toshihiro Morita,
Tatsushi Fujita
Publication year - 1993
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.61.149
Subject(s) - stimulant , ketamine , pharmacology , anesthesia , motor activity , medicine
The modification of the stimulant and motor-incoordinate actions of ketamine induced by repeated administration was investigated by means of ambulatory activity and rota-rod performance in mice, respectively. Ketamine (12.5, 25 and 50 mg/kg, s.c.) increased the mouse's ambulation in a dose-dependent manner, and the repeated 5-times administration at 3- to 4-day intervals enhanced the increment effect. However, a disruption of the rota-rod performance by ketamine was not modified by the repeated treatment. These results suggest that a reverse tolerance to the stimulant action of ketamine is produced, and that a tolerance to its motor-incoordinate action may not cause the enhancement.