Open AccessProtective Effect of Ifenprodil against Glucose Deprivation-Induced Damage in Cultured Rat Hippocampal Neurons
Author(s) -
Tadahiro Shikimi,
Keisuke Hattori,
Shuji Takaori
Publication year - 1997
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.60.97
Subject(s) - ifenprodil , hippocampal formation , neuroscience , endocrinology , medicine , biology , chemistry , nmda receptor , receptor
A human urinary trypsin inhibitor, urinastatin (UT)-like immunoreactive substance with trypsin inhibitory activity, was demonstrated in certain brain regions in rats, especially the cerebral cortex, hippocampus and hypothalamus. Although this UT-like substance in the rat brain displayed an N-terminal amino acid sequence similar to that of glyceraldehyde-3-phosphate dehydrogenase (GAPDH), it did not show any GAPDH activity. These results indicate that the UT-like substance in the rat brain is a protein different from GAPDH and indicates a localized distribution within certain brain regions partly related to learning and memory.