Continuous Infusion of β-Amyloid Protein into the Rat Cerebral Ventricle Induces Learning Impairment and Neuronal and Morphological Degeneration | Zendy

Atsumi Nitta | Zendy; Taneo Fukuta | Zendy; Takaaki Hasegawa | Zendy; Toshitaka Nabeshima | Zendy

Open Access

Continuous Infusion of β-Amyloid Protein into the Rat Cerebral Ventricle Induces Learning Impairment and Neuronal and Morphological Degeneration

Author(s) -

Atsumi Nitta,

Taneo Fukuta,

Takaaki Hasegawa,

Toshitaka Nabeshima

Publication year - 1997

Publication title -

the japanese journal of pharmacology

Language(s) - English

Resource type - Journals

eISSN - 1347-3506

pISSN - 0021-5198

DOI - 10.1254/jjp.60.51

Subject(s) - ischemia , medicine , cerebral edema , cerebrospinal fluid , ventricle , cerebral cortex , edema , platelet , pathology , anesthesia , endocrinology

Ischemia-like brain damage was induced in cats by selective injection of 4 beta-phorbol-12 beta-myristate-13 alpha-acetate (PMA) into the left carotid artery. PMA-injection provoked significant decreases in platelet and neutrophil counts due to their intravascular aggregation. Platelet and neutrophil aggregates caused brain edema with accumulation of sodium fluorescein in the cerebrospinal fluid and ipsilateral derangement of the cerebral energy state in the parietal cortex. Neurotropin administration decreased the changes in platelet and neutrophil counts and prevented the developments of both brain edema and cerebral energy failure.

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