New Ulcerative Colitis Model Induced by Sulfhydryl Blockers in Rats and the Effects of Antiinflammatory Drugs on the Colitis | Zendy

Hiroshi Satoh | Zendy; Fumihiko Sato | Zendy; Kenji Takami | Zendy; Sándor Szabó | Zendy

Open Access

New Ulcerative Colitis Model Induced by Sulfhydryl Blockers in Rats and the Effects of Antiinflammatory Drugs on the Colitis

Author(s) -

Hiroshi Satoh,

Fumihiko Sato,

Kenji Takami,

Sándor Szabó

Publication year - 1997

Publication title -

the japanese journal of pharmacology

Language(s) - English

Resource type - Journals

eISSN - 1347-3506

pISSN - 0021-5198

DOI - 10.1254/jjp.60.299

Subject(s) - ulcerative colitis , medicine , colitis , gastroenterology , iodoacetamide , inflammation , myeloperoxidase , pathogenesis , diarrhea , pharmacology , pathology , chemistry , disease , enzyme , cysteine , biochemistry

Phenylephrine displacement curves for the specific binding of [3H]prazosin in the membrane fraction prepared from rabbit thoracic aorta showed high- and low-affinity sites with slope factors significantly less than unity. The irreversible alpha 1B-antagonist phenoxybenzamine shifted the binding sites to single high affinity sites with a slope factor close to unity in the presence of the metabolically stable GTP analog GTP gamma-S. These results indicate that phenoxybenzamine may have affected selectively the low affinity site to phenylephrine in the presence of GTP gamma-S.

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