Open AccessSuppression by Azelastine Hydrochloride of NF-κB Activation Involved in Generation of Cytokines and Nitric Oxide
Author(s) -
Yukihiko Sugimoto,
Jun Yamada,
Ikuko Kimura,
Yoshihisa Watanabe,
Kazuyoshi Horisaka
Publication year - 1997
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.60.145
Subject(s) - hyperglucagonemia , endocrinology , glucagon , medicine , agonist , nitric oxide , buspirone , insulin , chemistry , receptor
The effects of the serotonin1A (5-HT1A) receptor agonist buspirone on the plasma glucose and pancreatic hormones insulin and glucagon were investigated in rats. Buspirone elicited significant hyperglycemia and hyperglucagonemia, although it did not affect the insulin levels. Adrenodemedullation inhibited both the increase in blood glucose and glucagon levels. These results indicate that buspirone-induced hyperglycemia and hyperglucagonemia are mediated by adrenaline release from the adrenal gland.