Suppression by Azelastine Hydrochloride of NF-κB Activation Involved in Generation of Cytokines and Nitric Oxide | Zendy

Kazunori Yoneda | Zendy; Tetsuya Yamamoto | Zendy; Eisaku Ueta | Zendy; Tokio Osaki | Zendy

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Suppression by Azelastine Hydrochloride of NF-κB Activation Involved in Generation of Cytokines and Nitric Oxide

Author(s) -

Kazunori Yoneda,

Tetsuya Yamamoto,

Eisaku Ueta,

Tokio Osaki

Publication year - 1997

Publication title -

the japanese journal of pharmacology

Language(s) - English

Resource type - Journals

eISSN - 1347-3506

pISSN - 0021-5198

DOI - 10.1254/jjp.60.145

Subject(s) - hyperglucagonemia , endocrinology , glucagon , medicine , agonist , nitric oxide , buspirone , insulin , chemistry , receptor

The effects of the serotonin1A (5-HT1A) receptor agonist buspirone on the plasma glucose and pancreatic hormones insulin and glucagon were investigated in rats. Buspirone elicited significant hyperglycemia and hyperglucagonemia, although it did not affect the insulin levels. Adrenodemedullation inhibited both the increase in blood glucose and glucagon levels. These results indicate that buspirone-induced hyperglycemia and hyperglucagonemia are mediated by adrenaline release from the adrenal gland.

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