Characterization of Subtype of Propylbenzilylcholine Mustard (PrBCM)-Sensitive and -Resistant Muscarinic Cholinoceptors in Guinea Pig Ileal Muscle | Zendy

Mariko Harada | Zendy; Katsuo Koike | Zendy; Issei Takayanagi | Zendy

Open Access

Characterization of Subtype of Propylbenzilylcholine Mustard (PrBCM)-Sensitive and -Resistant Muscarinic Cholinoceptors in Guinea Pig Ileal Muscle

Author(s) -

Mariko Harada,

Katsuo Koike,

Issei Takayanagi

Publication year - 1992

Publication title -

the japanese journal of pharmacology

Language(s) - English

Resource type - Journals

eISSN - 1347-3506

pISSN - 0021-5198

DOI - 10.1254/jjp.59.485

Subject(s) - muscarinic acetylcholine receptor , pirenzepine , guinea pig , carbachol , pilocarpine , medicine , endocrinology , biology , atropine , pharmacology , receptor , epilepsy , neuroscience , stimulation

The subtype of propylbenzilylcholine mustard (PrBCM)-sensitive and -resistant muscarinic cholinoceptors in guinea pig ileal muscle was examined using four selective muscarinic antagonists, pirenzepine, AF-DX 116, himbacine and 4-DAMP. The pA2 values of the four antagonists against pilocarpine were not different from their values against carbachol after the treatment with PrBCM and was identified with the values for the m3 subtype. These results suggest that the subtype of PrBCM-sensitive and -resistant muscarinic cholinoceptors in guinea pig ileal muscle is the m3 subtype only and not other subtypes.

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