Open AccessCharacterization of Subtype of Propylbenzilylcholine Mustard (PrBCM)-Sensitive and -Resistant Muscarinic Cholinoceptors in Guinea Pig Ileal Muscle
Author(s) -
Mariko Harada,
Kenichi Koike,
Issei Takayanagi
Publication year - 1992
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.59.485
Subject(s) - muscarinic acetylcholine receptor , pirenzepine , guinea pig , carbachol , pilocarpine , medicine , endocrinology , biology , atropine , pharmacology , receptor , epilepsy , neuroscience , stimulation
The subtype of propylbenzilylcholine mustard (PrBCM)-sensitive and -resistant muscarinic cholinoceptors in guinea pig ileal muscle was examined using four selective muscarinic antagonists, pirenzepine, AF-DX 116, himbacine and 4-DAMP. The pA2 values of the four antagonists against pilocarpine were not different from their values against carbachol after the treatment with PrBCM and was identified with the values for the m3 subtype. These results suggest that the subtype of PrBCM-sensitive and -resistant muscarinic cholinoceptors in guinea pig ileal muscle is the m3 subtype only and not other subtypes.