Tryptophan Inhibits the [3H] Glutamate Uptake into Xenopus Oocytes Injected with Rat Brain mRNA | Zendy

Michihisa Tohda | Zendy; Hisashi Urushihara | Zendy; Yasuyuki Nomura | Zendy

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Tryptophan Inhibits the [3H] Glutamate Uptake into Xenopus Oocytes Injected with Rat Brain mRNA

Author(s) -

Michihisa Tohda,

Hisashi Urushihara,

Yasuyuki Nomura

Publication year - 1992

Publication title -

the japanese journal of pharmacology

Language(s) - English

Resource type - Journals

eISSN - 1347-3506

pISSN - 0021-5198

DOI - 10.1254/jjp.59.477

Subject(s) - xenopus , messenger rna , glutamate receptor , chemistry , tryptophan , medicine , endocrinology , biology , amino acid , microbiology and biotechnology , biochemistry , gene , receptor

We characterized the glutamate (Glu) uptake in Xenopus oocytes injected with rat brain mRNA. The Glu uptake into oocytes was higher in mRNA-injected oocytes than in vehicle-injected ones. Na+ omission or addition of tryptophan inhibited the uptake in mRNA-injected oocytes, although it did not affect that in vehicle-injected oocytes. These results suggest that Glu transporters with a tryptophan sensitivity different from that of Glu transporters in native oocytes are expressed after injection of rat brain mRNA.

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