Effect of Ketotifen on Acute Gastric Lesions and Gastric Secretion in Rats | Zendy

Susumu Okabe | Zendy; Shigeru Nakaji | Zendy; Masaki Tachibana | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Effect of Ketotifen on Acute Gastric Lesions and Gastric Secretion in Rats

Author(s) -

Susumu Okabe,

Shigeru Nakaji,

Masaki Tachibana

Publication year - 1992

Publication title -

the japanese journal of pharmacology

Language(s) - English

Resource type - Journals

eISSN - 1347-3506

pISSN - 0021-5198

DOI - 10.1254/jjp.59.251

Subject(s) - ketotifen , histamine , secretion , gastric acid , antagonist , cimetidine , mast cell , gastric mucosa , basal (medicine) , medicine , gastric secretion , pharmacology , histamine h2 receptor , histamine h1 receptor , chemistry , endocrinology , stomach , receptor , immunology , asthma , insulin

Ketotifen, a histamine H1-receptor antagonist and mast cell stabilizer, significantly protected the rat gastric mucosa against lesions induced by necrotizing agents, histamine or compound 48/80. The agent significantly inhibited the basal gastric acid secretion, but had little or no effect on the histamine-stimulated secretion. The mucosal protective effect was observed even at a dose that had little or no effect on gastric acid secretion, suggesting that ketotifen exhibits so-called cytoprotective activity.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research