Open AccessEffect of Ketotifen on Acute Gastric Lesions and Gastric Secretion in Rats
Author(s) -
Susumu Okabe,
Shigeru Nakaji,
Masaki Terabe
Publication year - 1992
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.59.251
Subject(s) - ketotifen , histamine , secretion , gastric acid , antagonist , cimetidine , mast cell , gastric mucosa , basal (medicine) , medicine , gastric secretion , pharmacology , histamine h2 receptor , histamine h1 receptor , chemistry , endocrinology , stomach , receptor , immunology , asthma , insulin
Ketotifen, a histamine H1-receptor antagonist and mast cell stabilizer, significantly protected the rat gastric mucosa against lesions induced by necrotizing agents, histamine or compound 48/80. The agent significantly inhibited the basal gastric acid secretion, but had little or no effect on the histamine-stimulated secretion. The mucosal protective effect was observed even at a dose that had little or no effect on gastric acid secretion, suggesting that ketotifen exhibits so-called cytoprotective activity.