Nebracetam (WEB 1881FU) Prevents N-Methyl-D-Aspartate Receptor-Mediated Neurotoxicity in Rat Striatal Slices | Zendy

Yasufumi Kataoka | Zendy; Masami Niwa | Zendy; Shuichi Koizumi | Zendy; Shigenori Watanabe | Zendy; Masami Kouzuma | Zendy; Kohtaro Taniyama | Zendy

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Nebracetam (WEB 1881FU) Prevents N-Methyl-D-Aspartate Receptor-Mediated Neurotoxicity in Rat Striatal Slices

Author(s) -

Yasufumi Kataoka,

Masami Niwa,

Shuichi Koizumi,

Shigenori Watanabe,

Masami Kouzuma,

Kohtaro Taniyama

Publication year - 1992

Publication title -

the japanese journal of pharmacology

Language(s) - Uncategorized

Resource type - Journals

eISSN - 1347-3506

pISSN - 0021-5198

DOI - 10.1254/jjp.59.247

Subject(s) - nmda receptor , neurotoxicity , dopaminergic , glutamate receptor , neuroprotection , pharmacology , chemistry , dopamine , neuroscience , receptor , biology , medicine , toxicity , biochemistry

The effects of nebracetam were investigated on N-methyl-D-aspartate (NMDA) receptor- and voltage-operated Ca2+ channels (VOCC)-mediated neural dysfunction by directly monitoring the real-time dynamics of dopamine released from rat striatal slices. Nebracetam (10(-5) and 10(-4) M) completely protected against striatal dopaminergic impairment induced by L-glutamate and NMDA, respectively. BAY K-8644-evoked striatal dysfunction was not blocked by nebracetam (10(-4) M). Therefore, nebracetam seems to produce a neuroprotective action by interacting, at least in part, with NMDA receptor-operated Ca2+ channels.

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