Inhibitory Effect of NMDA on Dopaminergic Transmission in a Slice Preparation of Rat Globus Pallidus. | Zendy

Tomomi Shindou | Zendy; Shuichi Koizumi | Zendy; Yasufumi Kataoka | Zendy; Shigenori Watanabe | Zendy; Kenji Yamamoto | Zendy; Hiroshi Nakanishi | Zendy

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Inhibitory Effect of NMDA on Dopaminergic Transmission in a Slice Preparation of Rat Globus Pallidus.

Author(s) -

Tomomi Shindou,

Shuichi Koizumi,

Yasufumi Kataoka,

Shigenori Watanabe,

Kenji Yamamoto,

Hiroshi Nakanishi

Publication year - 1992

Publication title -

the japanese journal of pharmacology

Language(s) - English

Resource type - Journals

eISSN - 1347-3506

pISSN - 0021-5198

DOI - 10.1254/jjp.58.79

Subject(s) - nmda receptor , globus pallidus , bicuculline , dopaminergic , chemistry , inhibitory postsynaptic potential , dopamine , muscimol , neurotransmission , gaba receptor antagonist , neuroscience , pharmacology , gabaa receptor , biology , basal ganglia , receptor , central nervous system , biochemistry

The effect of N-methyl-D-aspartate (NMDA) on KCl-evoked endogenous dopamine (DA) release from slices of rat globus pallidus (GP) was examined. NMDA inhibited the KCl-evoked DA release in a dose-dependent manner. This inhibition was blocked by CPP, an NMDA antagonist. Tetrodotoxin partially antagonized the effect of NMDA. The NMDA-induced inhibition was also partially antagonized by bicuculline methiodide and was mimicked by muscimol. These results strongly suggest that 1) an activation of NMDA receptors exerts an inhibitory effect on dopaminergic transmission in GP and 2) GABAergic transmission is involved in the effect of NMDA.

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