Open AccessRole of PGE2 in Neurotransmission from Pre- to Post-Ganglionic Hypogastric Nerves of Guinea Pigs.
Author(s) -
Akikazu Fujita,
Tadayoshi Takeuchi,
Fumiaki Hata,
Osamu Yagasaki
Publication year - 1992
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.58.61
Subject(s) - hypogastric nerve , contraction (grammar) , stimulation , guinea pig , endocrinology , neurotransmission , medicine , vas deferens , tonic (physiology) , uterine contraction , inhibitory postsynaptic potential , reflex , chemistry , prostaglandin e2 , prostaglandin , biology , receptor , uterus
The hypogastric nerve to guinea pig vas deferens was stimulated pre- or post-ganglionically by adjusting the position of the suction electrode. Both stimulations induced a biphasic contraction consisting of a rapid transient phase and a delayed tonic phase. Indomethacin partially inhibited the contraction induced by pre-ganglionic stimulation, but did not inhibit that induced by post-ganglionic stimulation. Prostaglandin (PG) E2 counteracted the inhibitory effect of indomethacin. Mepacrine also inhibited the contraction induced by pre-ganglionic stimulation. Arachidonic acid and PGE2 both reversed the inhibition. The PGE2-receptor antagonist SC-19220 inhibited the contraction induced by pre-ganglionic, but not post-ganglionic nerve stimulation. These results suggested that endogenous PGE2 is important in neurotransmission in the pelvic ganglion of guinea pigs.