Open AccessThe Role of Mu- and Kappa-Opioid Receptors in Cocaine-Induced Conditioned Place Preference.
Author(s) -
Tsutomu Suzuki,
Y Shiozaki,
Yoshikazu Masukawa,
Miwa Misawa,
Hiroshi Nagase
Publication year - 1992
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.58.435
Subject(s) - naltrexone , conditioned place preference , antagonism , pharmacology , opioid , antagonist , agonist , buprenorphine , lithium chloride , κ opioid receptor , chemistry , psychology , receptor , morphine , medicine , biochemistry , organic chemistry
Effects of buprenorphine, U-50,488H, naltrexone and lithium chloride on cocaine conditioned place preference were examined. Buprenorphine, a mixed opioid agonist-antagonist, blocked the cocaine-induced place preference. Furthermore, the kappa-receptor agonist U-50,488H and the mu-receptor antagonist naltrexone both antagonized the cocaine preference. U-50,488H or naltrexone alone induced a place aversion in a dose-dependent manner. However, the cocaine-induced conditioned place preference was not blocked by lithium chloride, although the latter induced a conditioned place aversion, indicating that the antagonism of cocaine-induced place preference by U-50,488H or naltrexone does not result from a functional antagonism. These results suggest that mu- and kappa-opioid receptors may be involved in cocaine-induced conditioned place preference.