Effect of Indapamide on the Proliferation of Balb/C 3T3 Cells Induced by Platelet-Derived Growth Factor. | Zendy

Hisanobu Shimaji | Zendy; Hiroaki Shirahase | Zendy; Shigeyoshi Morishita | Zendy; Seimei Osumi | Zendy

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Effect of Indapamide on the Proliferation of Balb/C 3T3 Cells Induced by Platelet-Derived Growth Factor.

Author(s) -

Hisanobu Shimaji,

Hiroaki Shirahase,

Shigeyoshi Morishita,

Seimei Osumi

Publication year - 1991

Publication title -

the japanese journal of pharmacology

Language(s) - English

Resource type - Journals

eISSN - 1347-3506

pISSN - 0021-5198

DOI - 10.1254/jjp.57.609

Subject(s) - indapamide , platelet derived growth factor receptor , diuretic , fibroblast growth factor , growth factor , platelet derived growth factor , pharmacology , endocrinology , chemistry , medicine , biology , biochemistry , receptor

The effects of indapamide (a nonthiazide antihypertensive diuretic) on the growth promoting activity of serum, platelet-derived growth factor (PDGF), fibroblast growth factor (FGF) or Ca3(PO4)2 on Balb/C 3T3 cells were studied. Indapamide inhibited the growth promoting activity of serum, but furosemide (a nonthiazide antihypertensive diuretic) had no such inhibitory effect. Indapamide inhibited the growth promoting activity of PDGF, but not that of FGF and Ca3(PO4)2. The present experiments demonstrate that indapamide selectively inhibits the growth promoting activity of PDGF.

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