Open AccessEffect of Indapamide on the Proliferation of Balb/C 3T3 Cells Induced by Platelet-Derived Growth Factor.
Author(s) -
Hisanobu Shimaji,
Hiroaki Shirahase,
Shinya Morishita,
Seimei Osumi
Publication year - 1991
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.57.609
Subject(s) - indapamide , platelet derived growth factor receptor , diuretic , fibroblast growth factor , growth factor , platelet derived growth factor , pharmacology , endocrinology , chemistry , medicine , biology , biochemistry , receptor
The effects of indapamide (a nonthiazide antihypertensive diuretic) on the growth promoting activity of serum, platelet-derived growth factor (PDGF), fibroblast growth factor (FGF) or Ca3(PO4)2 on Balb/C 3T3 cells were studied. Indapamide inhibited the growth promoting activity of serum, but furosemide (a nonthiazide antihypertensive diuretic) had no such inhibitory effect. Indapamide inhibited the growth promoting activity of PDGF, but not that of FGF and Ca3(PO4)2. The present experiments demonstrate that indapamide selectively inhibits the growth promoting activity of PDGF.