Open AccessChronopharmacology of Trichlormethiazide in Rats: (III). Influence on Serum Triglyceride and Glucose.
Author(s) -
Akio Fujimura,
Tsuyoshi Shiga,
Kyoichi Ohashi,
Akio Ebihara
Publication year - 1991
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.57.437
Subject(s) - diuretic , triglyceride , medicine , endocrinology , body weight , pharmacology , chemistry , cholesterol
Trichlormethiazide was given orally to rats at 10 a.m. or 10 p.m. for 14 days. The diuretic effects of the agent at 10 a.m. were greater than those at 10 p.m. on day 14. Serum concentrations of triglyceride and glucose increased in both trials. The increments in these parameters were enhanced following trichlormethiazide at 10 a.m. These data indicate that the diuretic effects of trichlormethiazide and its untoward influences on serum metabolic parameters might vary with the administration time during a repeated therapy.