Open AccessEnhancement of Endogenous Prostaglandin I2 (Prostacyclin) Generation In Vivo by a Phenolic Anti-Inflammatory Agent in the Rabbit
Author(s) -
Michiko Kawamura,
Yoshiteru Harada,
Makoto Kikuchi
Publication year - 1991
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.57.113
Subject(s) - prostacyclin , chemistry , endogeny , in vivo , thromboxane b2 , thromboxane , prostaglandin , pharmacology , medicine , endocrinology , biochemistry , biology , platelet , microbiology and biotechnology
Angiotensin II (i.v.) increased the plasma level of 6-keto-PGF1 alpha from 241 +/- 60 pg/ml (n = 8) to 612 +/- 108 pg/ml (n = 8) in anesthetized rabbits, which was further significantly increased by pretreatment with a phenolic anti-inflammatory agent, MK-447, to 1007 +/- 218 pg/ml (n = 8). MK-447 alone did not affect the level. The level of thromboxane B2 was not affected by these treatments. These results suggest that MK-447 may selectively enhance the PGI2 level by acting as a tryptophan-like cofactor of PG endoperoxide synthase.