Effects of Genistein on ATP Induced DNA Synthesis and Intracellular Alkalinization in Chang Liver Cells | Zendy

K.H. Sit | Zendy; Kim-Ping Wong | Zendy; BoonHuat Bay | Zendy

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Effects of Genistein on ATP Induced DNA Synthesis and Intracellular Alkalinization in Chang Liver Cells

Author(s) -

K.H. Sit,

Kim-Ping Wong,

BoonHuat Bay

Publication year - 1991

Publication title -

the japanese journal of pharmacology

Language(s) - English

Resource type - Journals

eISSN - 1347-3506

pISSN - 0021-5198

DOI - 10.1254/jjp.57.109

Subject(s) - genistein , intracellular , dna synthesis , extracellular , adenosine triphosphate , cell growth , biology , stimulation , dna , cell , biochemistry , microbiology and biotechnology , endocrinology

Extracellular ATP (adenosine 5'-triphosphate) produces a dose-dependent elevation of DNA synthesis concomitantly with raised intracellular pH (pHi) in quiescent monolayer Chang liver cells. Genistein produces a dose-dependent suppression of ATP-induced DNA synthesis without affecting cell viability (dead cell index approximately 5%) or pHi elevation. The results suggest that (a) mitogenesis and pHi are not imperative correlates and (b) genistein is effective in inhibiting DNA synthesis whether due to growth factor or "non-growth factor" stimulation.

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