The Abilities of Specific .KAPPA.-Opioid Agonists, U-50,488H and U-62,066E, to Cause Antitussive Tolerance Were Lower than That of Morphine. | Zendy

Junzo Kamei | Zendy; Hiroaki Tanihara | Zendy; Yutaka Kasuya | Zendy

Open Access

The Abilities of Specific .KAPPA.-Opioid Agonists, U-50,488H and U-62,066E, to Cause Antitussive Tolerance Were Lower than That of Morphine.

Author(s) -

Junzo Kamei,

Hiroaki Tanihara,

Yutaka Kasuya

Publication year - 1991

Publication title -

the japanese journal of pharmacology

Language(s) - English

Resource type - Journals

eISSN - 1347-3506

pISSN - 0021-5198

DOI - 10.1254/jjp.56.557

Subject(s) - morphine , opioid , κ opioid receptor , kappa , agonist , pharmacology , drug tolerance , medicine , μ opioid receptor , chemistry , receptor , linguistics , philosophy

We examined whether the chronic administration of selective kappa-opioid agonists could produce antitussive tolerance, in a comparison with the mu-opioid morphine. A certain degree of tolerance to the antitussive effects of morphine appeared in rats treated chronically with this drug. However, chronic administration of U-50,488H and U-62,066E, highly selective agonists for the kappa-opioid receptor, does not result in the development of tolerance to their respective antitussive effects. These results suggest that the ability of kappa-opioid agonists to cause tolerance to their respective antitussive effects was lower than that of a mu-opioid agonist.

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