Open AccessEnhancement in .BETA.-Adrenergic Responsiveness of Adenylate Cyclase in Rat Liver after Galactosamine Administration.
Author(s) -
Shinichi Hatta,
Norihito Amemiya,
Hideyo Ohshika
Publication year - 1991
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.56.385
Subject(s) - adenylate kinase , forskolin , cyclase , medicine , endocrinology , galactosamine , chemistry , adrenergic , enzyme , biology , biochemistry , stimulation , receptor , glucosamine
In rat liver at 48 hours after galactosamine (GalN) treatment, isoproterenol-induced accumulation of cyclic AMP and activation of adenylate cyclase (AC) were significantly enhanced. AC activity stimulated with GppNHp or NaF was also augmented in membranes from GalN-treated rats. However, the MnCl2-stimulated or forskolin-stimulated activity in GalN-treated rats did not differ from the control. These data suggest that the beta-adrenergic responsiveness of AC in rat liver is potentiated, possibly due to the enhanced function of the Gs protein, during the process of regeneration after GalN treatment.