Open AccessInfluence of Heat Stimulation on the Amount of Calcitonin Gene-Related Peptide and Neurokinin A in the Subcutaneous Space of the Rat Hind Instep.
Author(s) -
Norifumi Yonehara,
Yasuo Imai,
Reizo Inoki
Publication year - 1991
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.56.381
Subject(s) - calcitonin gene related peptide , neurokinin a , capsaicin , substance p , stimulation , endocrinology , calcitonin , medicine , chemistry , neuropeptide , hindlimb , subcutaneous injection , sciatic nerve , neurokinin b , receptor
The release of tachykinins and calcitonin gene-related peptide (CGRP) into subcutaneous perfusates was investigated. Immersion of the hind paw of rats in water at 47 degrees C for 30 min led to a marked increase of immunoreactive CGRP (iCGRP) release as well as immunoreactive substance P release, but no detectable increase of immunoreactive neurokinin A release. Neonatal pretreatment with capsaicin or section of the sciatic and the saphenous nerves significantly inhibited the heat stimulation-induced release of iCGRP.