Influence of Heat Stimulation on the Amount of Calcitonin Gene-Related Peptide and Neurokinin A in the Subcutaneous Space of the Rat Hind Instep. | Zendy

Norifumi Yonehara | Zendy; Yasuo Imai | Zendy; Reizo Inoki | Zendy

Open Access

Influence of Heat Stimulation on the Amount of Calcitonin Gene-Related Peptide and Neurokinin A in the Subcutaneous Space of the Rat Hind Instep.

Author(s) -

Norifumi Yonehara,

Yasuo Imai,

Reizo Inoki

Publication year - 1991

Publication title -

the japanese journal of pharmacology

Language(s) - English

Resource type - Journals

eISSN - 1347-3506

pISSN - 0021-5198

DOI - 10.1254/jjp.56.381

Subject(s) - calcitonin gene related peptide , neurokinin a , capsaicin , substance p , stimulation , endocrinology , calcitonin , medicine , chemistry , neuropeptide , hindlimb , subcutaneous injection , sciatic nerve , neurokinin b , receptor

The release of tachykinins and calcitonin gene-related peptide (CGRP) into subcutaneous perfusates was investigated. Immersion of the hind paw of rats in water at 47 degrees C for 30 min led to a marked increase of immunoreactive CGRP (iCGRP) release as well as immunoreactive substance P release, but no detectable increase of immunoreactive neurokinin A release. Neonatal pretreatment with capsaicin or section of the sciatic and the saphenous nerves significantly inhibited the heat stimulation-induced release of iCGRP.

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