Open AccessExacerbation of Doxorubicin Toxicity by Chlorpromazine in Male ddY Mice.
Author(s) -
Masaaki Ishikawa,
Yoshio Takayanagi,
Kenichi Sasaki
Publication year - 1991
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.56.221
Subject(s) - chlorpromazine , exacerbation , lethality , toxicity , doxorubicin , pharmacology , medicine , long term potentiation , chemotherapy , median lethal dose , toxicology , biology , receptor
We examined whether chlorpromazine (CPZ) modulates the lethality of doxorubicin (DOX, 12 mg/kg, i.p.) in mice treated with CPZ (6 mg/kg, i.p.) 1 hr before administration of DOX. Pretreatment with CPZ produced: 1) earlier deaths and 2) an increase in the number of deaths, compared to the controls. Potentiation of the bone marrow toxicity of DOX by CPZ was also reflected in the drug lethality towards the animals.