Changes in CNS Levels of Serotonin and Its Metabolite in SART-Stressed(Repeatedly Cold-Stressed)Rats. | Zendy

Taeko Hata | Zendy; Eiji Itoh | Zendy; Atsufumi Kawabata | Zendy

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Changes in CNS Levels of Serotonin and Its Metabolite in SART-Stressed(Repeatedly Cold-Stressed)Rats.

Author(s) -

Taeko Hata,

Eiji Itoh,

Atsufumi Kawabata

Publication year - 1991

Publication title -

the japanese journal of pharmacology

Language(s) - English

Resource type - Journals

eISSN - 1347-3506

pISSN - 0021-5198

DOI - 10.1254/jjp.56.101

Subject(s) - metabolite , serotonin , neuroscience , medicine , biology , endocrinology , receptor

Central nervous system levels of serotonin (5-HT) and 5-hydroxy-indoleacetic acid (5-HIAA) in SART (specific alternation of rhythm in temperature)-stressed (repeatedly cold-stressed) rats were examined by HPLC-ECD. In SART-stressed rats, the levels of both 5-HT and 5-HIAA decreased in many brain areas. In the spinal cord, only the 5-HT level decreased. Therefore, the ratio of 5-HIAA to 5-HT increased only in the spinal cord. These results suggest that SART-stressed rats have some form of abnormality in the synthetic system of 5-HT.

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