Open AccessInhibition of Lipoxygenase by Phenolic compounds.
Author(s) -
Toshihiro Dohi,
Shinichi Anamura,
M Shirakawa,
Hiroshi Okamoto,
Akira Tsujimoto
Publication year - 1991
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.55.547
Subject(s) - guaiacol , eugenol , lipoxygenase , chemistry , cyclooxygenase , phenols , phenol , biochemistry , arachidonate 5 lipoxygenase , enzyme , arachidonic acid , organic chemistry
Eugenol dose-dependently inhibited 5-HETE (5-hydroxy-5,8,10, 14-eicosatetraenoic acid) and 15-HETE formation by human polymorphonuclear leucocytes. p-Chlorophenol, guaiacol and phenol also inhibited the lipoxygenases. Formation of HETEs by rat dental pulp was inhibited by eugenol and p-chlorophenol. The concentrations of the phenolics required to inhibit lipoxygenases were in the similar range with those used for inhibiting cyclooxygenase. These results showed that phenolic compounds inhibited lipoxygenases and thus suggest that these compounds may be dual inhibitors of lipoxygenase and cyclooxygenase.