Open AccessEffect of carvedilol on venous return: A mechanism of reduction in blood pressure.
Author(s) -
Takaharu Ishibashi,
Masayasu Okuhira,
Masami Hamaguchi,
Naoki Katsumata,
Makoto Nakazawa,
Shoichi Imai
Publication year - 1991
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.55.186
Subject(s) - venous return curve , vasodilation , blood pressure , medicine , anesthesia , peripheral resistance , venous blood , carvedilol , peripheral , cardiology , hemodynamics , heart rate , heart failure
We studied the effect of carvedilol, a beta-blocker with a potent alpha-blocking activity, on venous return in anesthetized dogs. Though 3 micrograms/kg of carvedilol caused a slight increase in blood pressure and total peripheral resistance, these changes disappeared by further doses of the agent. On the other hand, each dose of carvedilol (3-100 micrograms/kg) decreased venous return significantly and dose-dependently. These results indicate that the hypotensive effect of carvedilol mainly depends on the decrease in venous return rather than arterial vasodilation.