Effect of carvedilol on venous return: A mechanism of reduction in blood pressure. | Zendy

Takaharu Ishibashi | Zendy; Masayasu Okuhira | Zendy; Masami Hamaguchi | Zendy; Naoki Katsumata | Zendy; Mikio Nakazawa | Zendy; Shoichi Imai | Zendy

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Effect of carvedilol on venous return: A mechanism of reduction in blood pressure.

Author(s) -

Takaharu Ishibashi,

Masayasu Okuhira,

Masami Hamaguchi,

Naoki Katsumata,

Mikio Nakazawa,

Shoichi Imai

Publication year - 1991

Publication title -

the japanese journal of pharmacology

Language(s) - English

Resource type - Journals

eISSN - 1347-3506

pISSN - 0021-5198

DOI - 10.1254/jjp.55.186

Subject(s) - venous return curve , vasodilation , blood pressure , medicine , anesthesia , peripheral resistance , venous blood , carvedilol , peripheral , cardiology , hemodynamics , heart rate , heart failure

We studied the effect of carvedilol, a beta-blocker with a potent alpha-blocking activity, on venous return in anesthetized dogs. Though 3 micrograms/kg of carvedilol caused a slight increase in blood pressure and total peripheral resistance, these changes disappeared by further doses of the agent. On the other hand, each dose of carvedilol (3-100 micrograms/kg) decreased venous return significantly and dose-dependently. These results indicate that the hypotensive effect of carvedilol mainly depends on the decrease in venous return rather than arterial vasodilation.

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