Open AccessCapsaicin-sensitive afferent neurons in adaptive responses of the rat stomach induced by a mild irritant.
Author(s) -
Jiro Matsumoto,
Koji Ueshima,
Koji Takeuchi,
Susumu Okabe
Publication year - 1991
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.55.181
Subject(s) - capsaicin , stomach , desensitization (medicine) , chemistry , afferent , pharmacology , anesthesia , medicine , endocrinology , receptor
Exposure of rat stomach to 1 M NaCl reduced the transmucosal potential difference (PD) followed by an increase of luminal pH and gastric mucosal blood flow (GMBF). Desensitization of capsaicin-sensitive afferent neurons significantly mitigated the increase in GMBF without affecting PD and pH responses. Mucosal application of capsaicin increased GMBF with no effect on PD and pH. The findings suggest that capsaicin-sensitive afferent neurons may be involved in the regulatory mechanism of GMBF responses induced by a mild irritant.